Synergistic Effects of Novel Naphthoquinone Derivatives Against Clinical Methicilin-Resistant Staphylococcus aureus Strain
Résumé
The emergence of multidrug resistant (MDR) bacteria requires interest in the medical field and thereby an urgent need to develop efficient and specific methods in targeting unique bacterial cellular processes. Menadione (Vitamin K3) showed interesting properties as membrane integrity, two-component system and efflux pump disruptor. Novel series of 1,4-naphthoquinone based on menadione have been designed and synthesized starting from juglone and naphthazarin, following a Minisci-type reaction.
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