Robust Estimation of 5-ALA Induced PpIX Multiple-Wavelength Excitation Fluorescence Spectroscopy for Improving Glioma Classification
Résumé
Protoporphyrin IX (PpIX) is a fluorophore now used to identify tumoral tissues. The tissue is usually excited at one wavelength, e.g., 405 nm, and the fluorescence signal generated by this molecule and other fluorophores (the baseline) is used to estimate the amount of PpIX. However, fluorophores too close to PpIX impair the estimation and resulting classifications. Thus, we handle this issue by suggesting an efficient multi-excitation wavelengths method, free from any a priori on the baseline. Our method aims to distinguish healthy tissues from tumor margins, while being more robust to baseline variability. It keeps an ability to distinguish healthy from tumor tissues up to 87% in cases where existing methods'ability drops near 0%.
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