Integration of gene expression and DNA methylation identifies epigenetically controlled modules related to PM2.5 exposure - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Environment International Année : 2021

Integration of gene expression and DNA methylation identifies epigenetically controlled modules related to PM2.5 exposure

Daniel Aguilar
Åsa Wheelock
Olena Gruzieva

Résumé

Air pollution has been associated with adverse health effects across the life-course. Although underlying mechanisms are unclear, several studies suggested pollutant-induced changes in transcriptomic profiles. In this meta-analysis of transcriptome-wide association studies of 656 children and adolescents from three European cohorts participating in the MeDALL Consortium, we found two differentially expressed transcript clusters (FDR p < 0.05) associated with exposure to particulate matter < 2.5 µm in diameter (PM2.5) at birth, one of them mapping to the MIR1296 gene. Further, by integrating gene expression with DNA methylation using Functional Epigenetic Modules algorithms, we identified 9 and 6 modules in relation to PM2.5 exposure at birth and at current address, respectively (including NR1I2, MAPK6, TAF8 and SCARA3). In conclusion, PM2.5 exposure at birth was linked to differential gene expression in children and adolescents. Importantly, we identified several significant interactome hotspots of gene modules of relevance for complex diseases in relation to PM2.5 exposure.
Fichier principal
Vignette du fichier
Integration-of-gene-expression-and-DNA-methylation-identifi_2021_Environment.pdf (12.25 Mo) Télécharger le fichier
Origine : Fichiers éditeurs autorisés sur une archive ouverte

Dates et versions

hal-03659035 , version 1 (04-05-2022)

Licence

Paternité

Identifiants

Citer

Simon Kebede Merid, Mariona Bustamante, Marie Standl, Jordi Sunyer, Joachim Heinrich, et al.. Integration of gene expression and DNA methylation identifies epigenetically controlled modules related to PM2.5 exposure. Environment International, 2021, 146, pp.106248. ⟨10.1016/j.envint.2020.106248⟩. ⟨hal-03659035⟩
22 Consultations
9 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More