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Article Dans Une Revue GSC Biological and Pharmaceutical Sciences Année : 2021

Biologically relevant surrogates of coumarins: 2-phenyl H-isophosphinoline 2-oxides with antibacterial activity

Résumé

The present study aims to investigate the in vitro antibacterial activities of several isophosphinoline-2-oxides that can be perceived as combined bio isosteres of coumarins and flavonoids. More specifically, antibacterial activity was evaluated against four bacterial strains, including the Gram-negative bacteria Escherichia coli and Pseudomonas aeruginosa and the Gram-positive bacteria Staphylococcus aureus and Enterococcus faecalis by using disk diffusion assay. Notably, isophosphinoline-2-oxide compounds showed promising and highly selective antimicrobial activity against S. aureus
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hal-03578149 , version 1 (17-02-2022)

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Mina Hariri, Fatemeh Darvish, Karen-Pacelye Mengue Me Ndong, Rachida Babouri, Jacques Lebibi, et al.. Biologically relevant surrogates of coumarins: 2-phenyl H-isophosphinoline 2-oxides with antibacterial activity. GSC Biological and Pharmaceutical Sciences, 2021, 16, pp.283 - 296. ⟨10.30574/gscbps.2021.16.2.0252⟩. ⟨hal-03578149⟩
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