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Article Dans Une Revue Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontology Année : 2010

Biological properties of a neutralized 2.5% sodium hypochlorite solution

Résumé

Objectives. The objective of this study was to evaluate the influence of neutralizing a 2.5% NaOCl solution on its cytotoxicity, genotoxicity, and tissue-dissolving potential. Study design. The cytotoxicity and the genotoxicity of Dakin, a 2.5% NaOCl solution, and a neutralized 2.5% NaOCl solution were assessed according to ISO 10993 standards. The weight of palatal mucosa samples placed in neutralized 2.5% NaOCl, 2.5% NaOCl was recorded over time as well as the pH of the solutions. Results. The neutralized 2.5% NaOCl solution was 10-fold more cytotoxic than the 2.5% NaOCl solution. None of the solutions was genotoxic. The 2.5% NaOCl solution had a better tissue-dissolving capacity than the neutralized 2.5% NaOCl solution. The pH of the 2.5% NaOCl solution and neutralized 2.5% NaOCl solution decreased from 12 to 9 and from 7.5 to 5.6, respectively. Conclusion. Neutralizing a 2.5% NaOCl solution increased its cytotoxicity, did not induce any genotoxic effect, and reduced its tissue-dissolving ability.
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hal-03552071 , version 1 (02-02-2022)

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Virginie Aubut, Ludovic Pommel, Bernard Verhille, Thierry Orsière, Serge S. Garcia, et al.. Biological properties of a neutralized 2.5% sodium hypochlorite solution. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontology, 2010, 109 (2), pp.e120-e125. ⟨10.1016/j.tripleo.2009.09.022⟩. ⟨hal-03552071⟩
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