The anisotropic material behaviour of a recrystallized AA2198 Al-Cu-Li alloy in T3 and T8 conditions was assessed by proportional loading of uniaxial-tension specimens in rolling (L), transverse (T) and diagonal (D) orientations. The width and longitudinal strains were measured to quantify plastic anisotropy. Notched-tension samples were tested in L and T directions. The material showed weak anisotropy in terms of stress strain curves and a moderate plastic anisotropy, consistent with its texture obtained by EBSD. An anisotropic Bron-Besson type material model was identified using this data base and a micro shear-only (SO) test. The model succeeded in predicting the behaviour of micro specimens for proportional tension-only (TO) loading and non-proportional load path changes including 'shear to tension' (ST) as well as 'tension to shear' (TS) tests. The non-proportional loading was achieved using a newly designed cross shaped sample. It was loaded in one direction, unloaded and subsequently loaded in the orthogonal direction till fracture. The average stretch to fracture of both alloys measured by a four point frame optical extensometer decreased by 29 % and 16 % for T3 and T8 respectively for the 'shear to tension' experiment compared to the proportional TO experiment. The average stretch to fracture of 'tension to shear' tests was reduced by 10 % for 2198T3 and hardly reduced for 2198T8 compared to the stretch to fracture of the SO tests, but subject to strong scatter. FE simulations showed local accumulated strain to fracture values that were similar for all loading histories for the T8 condition (0.73 − 0.84). Lower strain to fracture values were found in T3 condition (0.45 − 0.73), despite the enhanced macroscopic ductility in tension. This was attributed to larger less localized plastic zones, especially for the ST test. The ductility scatter was attributed to necking and damage development in tension that can affect strain localization, associated fracture path and ductility, as observed by DIC and fractography.