A design is a collection of distinct points in a given set X, which is assumed to be a compact subset of R^d , and the mesh-ratio of a design is the ratio of its fill distance to its separation radius. The uniformity constant of a sequence of nested designs is the smallest upper bound for the mesh-ratios of the designs. We derive a lower bound on this uniformity constant and show that a simple greedy construction achieves this lower bound. We then extend this scheme to allow more flexibility in the design construction.