Abstract In the past, several destructive earthquakes have occurred in the North African Atlas Mountain ranges located along the Africa–Eurasia plate boundary. Although the region is rich with impressive archaeological sites, including those in modern Tunisia, few comprehensive archaeoseismological studies have been conducted. Historic sources account at least three damaging earthquakes in the Kairouan area in central Tunisia between AD 859 and 1041. Little is known about which faults triggered these earthquakes or the size of these events. The water supply of the city of Kairouan depended on a 32-km-long aqueduct with a large bridge (now partially collapsed) at the confluence of the de Mouta and Cherichira rivers. The original bridge of Roman construction was retrofitted twice during the Aghlabid period (AD 800–903) and probably in AD 995 during the Fatimid period. The ruined section of the bridge shows damage which might be related to the AD 859 earthquake shaking. Here, we present a detailed study of the history, the status and the damage of the Cherichira aqueduct bridge using previous historic accounts and written works, a 3D laser scan model, local geological and seismological characteristics, and include results of radiocarbon dating and a timeline of events. In addition to earthquake ground motions, we consider severe flash floods on the bridge as a potential cause of the damage. We estimate the severity of such flash floods and develop a model with 18 earthquake scenarios on local reverse and strike-slip faults with magnitudes between M W 6.1 and 7.2. While a few damage patterns might be indicative of flooding, most damage can be attributed to earthquakes. It is highly probable that the earthquake in AD 859 caused enough damage to the Aghlabid bridge to render it dysfunctional; however, to resolve the question of whether another earthquake in AD 911 or 1041 caused the complete destruction of the previously retrofitted aqueduct by the Fatimids requires dating of additional sections of the bridge.