Increased Collagen Turnover Is a Feature of Fibromuscular Dysplasia and Associated With Hypertrophic Radial Remodeling: A Pilot, Urine Proteomic Study. - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Hypertension Année : 2021

Increased Collagen Turnover Is a Feature of Fibromuscular Dysplasia and Associated With Hypertrophic Radial Remodeling: A Pilot, Urine Proteomic Study.

A Latosinska
  • Fonction : Auteur
Rm Bruno
  • Fonction : Auteur
M Pappaccogli
  • Fonction : Auteur
A Bacca
  • Fonction : Auteur
C Beauloye
  • Fonction : Auteur
P Boutouyrie
  • Fonction : Auteur
H Khettab
  • Fonction : Auteur
Ja Staessen
  • Fonction : Auteur
S Taddei
  • Fonction : Auteur
M Vikkula
  • Fonction : Auteur
H Mischak
  • Fonction : Auteur
A Persu
  • Fonction : Auteur

Résumé

Fibromuscular dysplasia (FMD), a nonatherosclerotic, noninflammatory disease of medium-sized arteries, is an underdiagnosed disease. We investigated the urinary proteome and developed a classifier for discrimination of FMD from healthy controls and other diseases. We further hypothesized that urinary proteomics biomarkers may be associated with alterations in medium-sized, but not large artery geometry and mechanics. The study included 33 patients with mostly multifocal, renal FMD who underwent in depth arterial exploration using ultra-high frequency ultrasound. The cohort was separated in a training set of 23 patients with FMD from Belgium and an independent test set of 10 patients with FMD from Italy. For each set, controls matched 2:1 were selected from the Human Urinary Proteome Database. The specificity of the classifier was tested in 700 additional controls from general population studies, patients with chronic kidney disease (n=66) and coronary artery disease (n=31). Three hundred thirty-five urinary peptides, mostly related to collagen turnover, were identified in the training cohort and combined into a classifier. When applying in the test cohort, the area under the receiver operating characteristic curve was 1.00, 100% specificity at 100% sensitivity. The classifier maintained a high specificity in additional controls (98.3%), patients with chronic kidney (90.9%) and coronary artery (96.8%) diseases. Furthermore, in patients with FMD, the proteomic score was positively associated with radial wall thickness and wall cross-sectional area. In conclusion, a proteomic score has the potential to discriminate between patients with FMD and controls. If confirmed in a wider and more diverse cohort, these findings may pave the way for a noninvasive diagnostic test of FMD.
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Dates et versions

hal-03467686 , version 1 (06-12-2021)

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  • HAL Id : hal-03467686 , version 1

Citer

A Latosinska, Rm Bruno, M Pappaccogli, A Bacca, C Beauloye, et al.. Increased Collagen Turnover Is a Feature of Fibromuscular Dysplasia and Associated With Hypertrophic Radial Remodeling: A Pilot, Urine Proteomic Study.. Hypertension, 2021, pp.HYPERTENSIONAHA12118. ⟨hal-03467686⟩
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