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            <title xml:lang="en">Increased Collagen Turnover Is a Feature of Fibromuscular Dysplasia and Associated With Hypertrophic Radial Remodeling: A Pilot, Urine Proteomic Study.</title>
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              <date type="whenSubmitted">2021-12-06 16:26:22</date>
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            <idno type="halRefHtml">&lt;i&gt;Hypertension&lt;/i&gt;, 2021, pp.HYPERTENSIONAHA12118</idno>
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            <idno type="stamp" n="UNIV-PARIS13">Université Paris-Nord - Paris XIII </idno>
            <idno type="stamp" n="LIMICS" corresp="SORBONNE-UNIVERSITE">Laboratoire d'Informatique Médicale et Ingénierie des Connaissances en e-Santé</idno>
            <idno type="stamp" n="SORBONNE-UNIVERSITE">Sorbonne Université</idno>
            <idno type="stamp" n="SORBONNE-UNIV" corresp="SORBONNE-UNIVERSITE">Sorbonne Université 01/01/2018</idno>
            <idno type="stamp" n="SU-SCIENCES" corresp="SORBONNE-UNIVERSITE">Faculté des Sciences de Sorbonne Université</idno>
            <idno type="stamp" n="SORBONNE-PARIS-NORD">Université Sorbonne Paris Nord</idno>
            <idno type="stamp" n="ALLIANCE-SU"> Alliance Sorbonne Université</idno>
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                <title xml:lang="en">Increased Collagen Turnover Is a Feature of Fibromuscular Dysplasia and Associated With Hypertrophic Radial Remodeling: A Pilot, Urine Proteomic Study.</title>
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                    <surname>Beauloye</surname>
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                    <forename type="first">Ja</forename>
                    <surname>Staessen</surname>
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                    <surname>Toubiana</surname>
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                    <surname>Vikkula</surname>
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                <idno type="eissn">1524-4563</idno>
                <title level="j">Hypertension</title>
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                  <publisher>American Heart Association</publisher>
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                  <date type="datePub">2021-11-17</date>
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                <term xml:lang="en">kidney</term>
                <term xml:lang="en">hypertension</term>
                <term xml:lang="en">collagen</term>
                <term xml:lang="en">fibromuscular dysplasia</term>
              </keywords>
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              <p>Fibromuscular dysplasia (FMD), a nonatherosclerotic, noninflammatory disease of medium-sized arteries, is an underdiagnosed disease. We investigated the urinary proteome and developed a classifier for discrimination of FMD from healthy controls and other diseases. We further hypothesized that urinary proteomics biomarkers may be associated with alterations in medium-sized, but not large artery geometry and mechanics. The study included 33 patients with mostly multifocal, renal FMD who underwent in depth arterial exploration using ultra-high frequency ultrasound. The cohort was separated in a training set of 23 patients with FMD from Belgium and an independent test set of 10 patients with FMD from Italy. For each set, controls matched 2:1 were selected from the Human Urinary Proteome Database. The specificity of the classifier was tested in 700 additional controls from general population studies, patients with chronic kidney disease (n=66) and coronary artery disease (n=31). Three hundred thirty-five urinary peptides, mostly related to collagen turnover, were identified in the training cohort and combined into a classifier. When applying in the test cohort, the area under the receiver operating characteristic curve was 1.00, 100% specificity at 100% sensitivity. The classifier maintained a high specificity in additional controls (98.3%), patients with chronic kidney (90.9%) and coronary artery (96.8%) diseases. Furthermore, in patients with FMD, the proteomic score was positively associated with radial wall thickness and wall cross-sectional area. In conclusion, a proteomic score has the potential to discriminate between patients with FMD and controls. If confirmed in a wider and more diverse cohort, these findings may pave the way for a noninvasive diagnostic test of FMD.</p>
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