The thermal comfort requirements of disabled people in healthcare buildings are an important research topic that concerns a specific population with medical conditions impacted by the indoor environment. This paper experimentally investigated adaptive thermal comfort in buildings belonging to the Association of Parents of Disabled Children, located in the city of Troyes, France, during the winter season. Thermal comfort was evaluated using subjective measurements and objective physical parameters. The thermal sensations of respondents were determined by questionnaires adapted to their disability. Indoor environmental parameters such as relative humidity, mean radiant temperature, air temperature, and air velocity were measured using a thermal microclimate station during winter in February and March 2020. The main results indicated a strong correlation between operative temperature, predicted mean vote, and adaptive predicted mean vote, with the adaptive temperature estimated at around 21.65 °C. These findings highlighted the need to propose an adaptive thermal comfort strategy. Thus, a new adaptive model of the predicted mean vote was proposed and discussed, with a focus on the relationship between patient sensations and the thermal environment.