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Article Dans Une Revue Head & Neck Année : 2021

Radioresistance and genomic alterations in head and neck squamous cell cancer: Sub‐analysis of the ProfiLER protocol

Elise Rowinski
  • Fonction : Auteur
Jérôme Fayette
  • Fonction : Auteur
Elisabeth Daguenet
Séverine Racadot
  • Fonction : Auteur
Pascal Pommier
  • Fonction : Auteur
Benoîte Méry
  • Fonction : Auteur
Alexis Vallard
  • Fonction : Auteur
Fabien Tinquaut
  • Fonction : Auteur
Eve‐marie Neidhardt‐berard
  • Fonction : Auteur
Philippe Cassier
  • Fonction : Auteur
Valéry Attignon
  • Fonction : Auteur
Daniel Pissaloux
  • Fonction : Auteur
  • PersonId : 768539
  • IdRef : 17847147X
Qing Wang
  • Fonction : Auteur
Emilie Sohier
  • Fonction : Auteur
David Pérol
  • Fonction : Auteur
Jean‐yves Blay
Olivier Trédan

Résumé

Background Genome analysis could provide tools to assess predictive molecular biomarkers of radioresistance. Methods Head and neck squamous cell carcinoma patients included in ProfiLER study and who underwent a curative radiotherapy were screened. Univariate and Cox multivariate analyses were performed to explore the relationships between molecular abnormalities, infield relapse and complete tumor response after radiation. Results One hundred and forty-three patients were analyzed. PIK3CA mutation and genomic instability of MAP kinases pathway were found to be prognostic factors of loco-regional relapse in multivariate analysis with respectively HR 0.33, 95% CI 0.13–0.83, p = 0.005 and HR 0.61, 95% CI 0.38–0.96, p = 0.025. Instability of apoptosis pathway was found to be a prognostic factor of complete response after radiotherapy with HR 0.24, 95% CI 0.07–0.88, p = 0.04. Conclusion This sub analysis suggests that PIK3CA mutation, variation of copy number of MAP kinases and apoptosis pathways play a significant role in the radioresistance phenomenon
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Dates et versions

hal-03461669 , version 1 (01-12-2021)

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Elise Rowinski, Nicolas Magné, Jérôme Fayette, Elisabeth Daguenet, Séverine Racadot, et al.. Radioresistance and genomic alterations in head and neck squamous cell cancer: Sub‐analysis of the ProfiLER protocol. Head & Neck, 2021, 43 (12), pp.3899-3910. ⟨10.1002/hed.26891⟩. ⟨hal-03461669⟩
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