Iridium(III) Catalyzed Z-Selective Allylic Arylation of α-Fluoro But-1-enoic Acid Amides via β-F-Elimination in Water - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Organic Letters Année : 2021

Iridium(III) Catalyzed Z-Selective Allylic Arylation of α-Fluoro But-1-enoic Acid Amides via β-F-Elimination in Water

Résumé

Allylic arylation of -fluoro but-1-enoic acid amides with arylboronic acids was carried out in water by comparing the cata-lytic activity of iridium(III) and rhodium (III). Ir(III) has shown a strong superiority over Rh(III) to give allyl-aryl coupling products with excellent stereoselectivity in favor of the Z isomer. The origin of high stereoselectivity is perhaps because of the a coordination of iridium Ir-N or Ir-O.

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Chimie
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hal-03447277 , version 1 (24-11-2021)

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Clément Casalta, Christophe Gourlaouen, Samir Bouzbouz. Iridium(III) Catalyzed Z-Selective Allylic Arylation of α-Fluoro But-1-enoic Acid Amides via β-F-Elimination in Water. Organic Letters, 2021, ⟨10.1021/acs.orglett.1c02054⟩. ⟨hal-03447277⟩
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