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Article Dans Une Revue EP-Europace Année : 2021

ESC working group on cardiac cellular electrophysiology position paper: relevance, opportunities, and limitations of experimental models for cardiac electrophysiology research

Katja Odening
Ana-Maria Gomez
  • Fonction : Auteur
Dobromir Dobrev
  • Fonction : Auteur
Larissa Fabritz
Frank Heinzel
  • Fonction : Auteur
Matteo E Mangoni
Cristina Molina
  • Fonction : Auteur
Leonardo Sacconi
Godfrey Smith
  • Fonction : Auteur
Milan Stengl
  • Fonction : Auteur
Dierk Thomas
  • Fonction : Auteur
Antonio Zaza
Carol Ann Remme
  • Fonction : Auteur
Jordi Heijman

Résumé

Abstract Cardiac arrhythmias are a major cause of death and disability. A large number of experimental cell and animal models have been developed to study arrhythmogenic diseases. These models have provided important insights into the underlying arrhythmia mechanisms and translational options for their therapeutic management. This position paper from the ESC Working Group on Cardiac Cellular Electrophysiology provides an overview of (i) currently available in vitro, ex vivo, and in vivo electrophysiological research methodologies, (ii) the most commonly used experimental (cellular and animal) models for cardiac arrhythmias including relevant species differences, (iii) the use of human cardiac tissue, induced pluripotent stem cell (hiPSC)-derived and in silico models to study cardiac arrhythmias, and (iv) the availability, relevance, limitations, and opportunities of these cellular and animal models to recapitulate specific acquired and inherited arrhythmogenic diseases, including atrial fibrillation, heart failure, cardiomyopathy, myocarditis, sinus node, and conduction disorders and channelopathies. By promoting a better understanding of these models and their limitations, this position paper aims to improve the quality of basic research in cardiac electrophysiology, with the ultimate goal to facilitate the clinical translation and application of basic electrophysiological research findings on arrhythmia mechanisms and therapies.
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Dates et versions

hal-03437471 , version 1 (20-11-2021)

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Katja Odening, Ana-Maria Gomez, Dobromir Dobrev, Larissa Fabritz, Frank Heinzel, et al.. ESC working group on cardiac cellular electrophysiology position paper: relevance, opportunities, and limitations of experimental models for cardiac electrophysiology research. EP-Europace, 2021, 23 (11), pp.1795-1814. ⟨10.1093/europace/euab142⟩. ⟨hal-03437471⟩
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