Stem Cells to Decipher the Physiological Roles of 5-HT2B Receptor Signaling
Résumé
The serotonergic 2B receptor (5-HT 2B R), expressed in the central nervous system and at the periphery, contributes to the regulation of several physiological processes such as cardio-vascular, pulmonary, bone and neuronal functions. Due to its multifaceted roles, signaling pathways and cell targets controlled by the 5-HT 2B R are still the subject of intensive research. Here, we review how exploiting the dynamics of differentiation of the 1C11 neuronal stem cell line allows to identify several 5-HT 2B R-coupled signaling pathways and targets, among which the serotonin transporter, involved in the homeostasis of serotonergic neurons and their adaptive response to selective serotonin-reuptake inhibitors (SSRIs) like fluoxetine (Prozac ®). In addition mesoblastic stem cell lines permit to show that along the osteogenic differentiation, the 5-HT 2B R controls the activity of the tissue-non-specific alkaline phosphatase, a major enzyme for bone formation. Finally the 5-HT 2B R expressed by pulpal stem cells takes part to natural tooth repair upon 5-HT release by injury-activated platelets.
Origine : Fichiers produits par l'(les) auteur(s)