Synthesis and biological studies of new piperidino-1,2,3-triazole hybrids with 3-aryl isoxazole side chains
Résumé
A small library of new piperidine-triazole hybrids with 3-aryl isoxazole side chains has been designed and synthesized. Their cytotoxicity against a panel of seven cancer cell lines has been established. For the most promising compound, an IC(50) value of 3.8 μM on PUMA/Bcl-xL interaction in live cancer cells was established through BRET analysis. A rationale was proposed for these results through complete molecular modelling studies.
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Murthy et al-2021-Synthesis and biological studies of new piperidino-1,2,3-triazole hybrids with.pdf (1.75 Mo)
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Murthy_1-s2.0-S0960894X2100617X-mmc1.pdf (5.24 Mo)
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