One-Pot Synthesis of Pyrrolo[1,2-f]phenanthridines From 1-Arylpyrroles via Successive Palladium-Catalyzed Direct Arylations
Résumé
A Pd-catalyzed annulative pi-extension reaction of 1-arylpyrroles using 1,2-dihalobenzenes as the coupling partners was investigated. The higher reactivity of pyrrole C2-H bond compared to C-H bonds of the aryl unit of 1-arylpyrroles allows selective synthesis of pyrrolo[1,2-f]phenanthridines via successive palladium-catalyzed direct intermolecular followed by intramolecular direct arylation steps. From 1-bromo-2-iodobenzenes bearing substituents at C4- or C5-positions and ortho-, meta- or para-substituted 1-arylpyrroles, the access to pyrrolo[1,2-f]phenanthridines containing substituents at C5, C6, C7, C8, C10 and/or C11 positions is possible.
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Zhang et al - 2021 - One-Pot Synthesis of Pyrrolo[1,2-f]phenanthridines_EJOC Rev Jian Final.pdf (1.18 Mo)
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Zhang_ejoc202100766-sup-0001-misc_information.pdf (5.82 Mo)
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