Versatile Access to Tetrasubstituted 2-Amidoacroleins through Formal Silylformylation of Ynamides
Résumé
In this paper we are reporting the first regio-and stereo-selective silylformylation of ynamides. This reaction is tolerant to a wide range of functional groups around the ynamides. The substitution of CO by an isocyanide makes this reaction safer and more practical than standard silylformylation reactions. It overall represents a versatile and rapid access to various tetrasubstituted 3-silyl-2-amidoacrolein derivatives. The synthetic potential of these new building blocks has been evaluated by performing several post-functionalization.
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