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Article Dans Une Revue Organic Letters Année : 2021

Versatile Access to Tetrasubstituted 2-Amidoacroleins through Formal Silylformylation of Ynamides

Résumé

In this paper we are reporting the first regio-and stereo-selective silylformylation of ynamides. This reaction is tolerant to a wide range of functional groups around the ynamides. The substitution of CO by an isocyanide makes this reaction safer and more practical than standard silylformylation reactions. It overall represents a versatile and rapid access to various tetrasubstituted 3-silyl-2-amidoacrolein derivatives. The synthetic potential of these new building blocks has been evaluated by performing several post-functionalization.
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Dates et versions

hal-03369636 , version 1 (07-10-2021)

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Stéphane Golling, Frédéric R. Leroux, Morgan Donnard. Versatile Access to Tetrasubstituted 2-Amidoacroleins through Formal Silylformylation of Ynamides. Organic Letters, 2021, 23, pp.8093-8097. ⟨10.1021/acs.orglett.1c03141⟩. ⟨hal-03369636⟩
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