The control of cyber-physical systems (CPS) is a great challenge for researchers in control theory and engineering mainly because of delays induced by merging computation, communication, and control of physical processes. Consequently, control solutions for time-delay systems can be applied efficiently for many CPS system configurations. In this article, a fractional order PIλ and PIλDµ control design is investigated for a class of fractional order time-delay systems. The proposed control design approach is simple and efficient. The controller parameter's adjustment is achieved in two steps: first, the relay approach is used to compute satisfactory classical PID coefficients, namely kp, Ti and Td. Then, the fractional orders λ and µ are optimized using performance criteria. Simulation results show the efficiency of the proposed design technique and its ability to enhance the PID control performance.