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Article dans une revue Toxicon Année : 2021

A therapeutic oxygen carrier isolated from Arenicola marina decreases amanitin-induced hepatotoxicity

Résumé

The amanitins (namely α- and β-amanitin) contained in certain mushrooms are bicyclic octapeptides that, when ingested, are responsible for potentially lethal hepatotoxicity. M101 is an extracellular hemoglobin extracted from the marine worm Arenicola marina. It has intrinsic Cu/Zn-SOD-like activity and is currently used as an oxygen carrier in organ preservation solutions. Our present results suggest that M101 might be effective in reducing amanitin-induced hepatotoxicity and may have potential for therapeutic development.
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Dates et versions

hal-03334103, version 1 (18-10-2021)

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Brendan Le Daré, Pierre-Jean Ferron, Nessrine Bellamri, Catherine Ribault, Eric Delpy, et al.. A therapeutic oxygen carrier isolated from Arenicola marina decreases amanitin-induced hepatotoxicity. Toxicon, 2021, 200, pp.87-91. ⟨10.1016/j.toxicon.2021.07.004⟩. ⟨hal-03334103⟩
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