Synthesis of Lactams by Reductive Amination of Carbonyl Derivatives with omega-Amino Fatty Acids under Hydrosilylation Conditions
Résumé
An efficient method for the preparation of lactams from omega-amino fatty acids under hydrosilylation is described. A variety of lactams such as pyrrolidinones, piperidinones and 2-azepanones were selectively synthesised in moderate to excellent yields (29 examples, up to 95 % isolated yields) with a good functional group tolerance. Notably, no metallic based catalyst was required to perform this transformation.
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Tongdee et al - 2021 - Synthesis of Lactams by Reductive Amination of Carbonyl Derivatives - accepted manuscript ejoc.202100719R1.pdf (1.98 Mo)
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Tongdee_ejoc202100719-sup-0001-misc_information.pdf (2.87 Mo)
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