Article Dans Une Revue Cancer Genomics and Proteomics Année : 2021

Genetic Analysis in Anal and Cervical Cancer: Exploratory Findings About Radioresistance in the ProfiLER Database

Elise Rowinski
  • Fonction : Auteur
Wafa Bouleftour
Pablo Moreno-Acosta
  • Fonction : Auteur
Christelle de La Fourchadiere
  • Fonction : Auteur
Isabelle Ray-Coquard
Qing Wang
  • Fonction : Auteur
Jean-Yves Blay
Olivier Tredan

Résumé

Background/Aim: This study aimed to describe genomic alterations on squamous cell cervical and anal carcinomas. Materials and Methods: From 2013 to 2019, 3,269 patients were included in the molecular screening ProfiLER trial. Only patients with non-metastatic cervical or anal cancer, and those initially treated with radiotherapy in a curative intent were selected. Genetic analyses were performed by next generation sequencing (NGS). Results: Genomic alterations were observed in most patients: 5 patients out of 15 (33.3%) had at least one mutation on NGS and 4 out of 15 (26.7%) had at least one aberration of the number of copies of genes in the comparative genomic hybridation (CGH) analysis. The most common mutated gene was PIK3CA. Conclusion: All omic approaches must be integrated in the locally advanced cancer setting by new clinical trial design to develop two routes in the treatment strategy: intensification or de-escalation treatment strategy according to omic markers

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hal-03323257 , version 1 (27-08-2021)

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Elise Rowinski, Nicolas Magne, Wafa Bouleftour, Pablo Moreno-Acosta, Christelle de La Fourchadiere, et al.. Genetic Analysis in Anal and Cervical Cancer: Exploratory Findings About Radioresistance in the ProfiLER Database. Cancer Genomics and Proteomics, 2021, 18 (4), pp.515-520. ⟨10.21873/cgp.20276⟩. ⟨hal-03323257⟩
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