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Article Dans Une Revue Biomedizinische Technik. Ergänzungsband (Berlin. Zeitschrift) Année : 2005

Modelling ultrasonic backscattering of an SPIO-MRI contrast agent

Résumé

The ultrasonic backscatter coefficient (BSC) of superparamagnetic iron oxide (SPIO) nanoparticles, which are used as a liver MRI contrast agent, was simulated using a Yagi backscattering model. The BSC of SPIO cores that are aggregated in the lysosomes of Kupffer cells is significantly higher (85 dB) than the BSC of nonaggregated SPIO cores. Considering in vivo concentrations, the aggregated SPIO does not elevate the BSC of the liver markedly (9x10-6 dB). Thus, the reported visibility of SPIO in clinical ultrasound cannot be explained by classical scattering theory. Other non-linear effects need to be taken into account.
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hal-03189337 , version 1 (03-04-2021)

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  • HAL Id : hal-03189337 , version 1

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Martin P Mienkina, Michiel Postema, Christian Hansen, Georg Schmitz. Modelling ultrasonic backscattering of an SPIO-MRI contrast agent. Biomedizinische Technik. Ergänzungsband (Berlin. Zeitschrift), 2005, Medical Physics: Proceedings of the jointly held Congresses ICMP 2005 14th International Conference of Medical Physics of the International Organization for Medical Physics (IOMP), the European Federation of Organizations in Medical Physics (EFOMP) and the German Society of Medical Physics (DGMP); BMT 2005 39th Annual Congress of the German Society for Biomedical Engineering (DGBMT) within VDE 14th -17th September 2005, Nuremberg, Germany, 50 (Suppl. 1), pp.750-751. ⟨hal-03189337⟩
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