Remote-sensing time-series data are significant for global environmental change research and a better understanding of the Earth. However, remote-sensing acquisitions often provide sparse time series due to sensor resolution limitations and environmental factors, such as cloud noise for optical data. Image interpolation is the method that is often used to deal with this issue. This paper considers the deep learning method to learn the complex mapping of an interpolated intermediate image from predecessor and successor images, called separable convolution network for sequence image interpolation. The separable convolution network uses a separable 1D convolution kernel instead of 2D kernels to capture the spatial characteristics of input sequence images and then is trained end-to-end using sequence images. Our experiments, which were performed with unmanned aerial vehicle (UAV) and Landsat-8 datasets, show that the method is effective to produce high-quality time-series interpolated images, and the data-driven deep model can better simulate complex and diverse nonlinear image data information.