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Article Dans Une Revue Chemistry Année : 2020

Selective Proton-Mediated Transport by Electrogenic K+-Binding Macrocycles

Résumé

Synthetic K +-binding macrocycles have potential as therapeutic agents for diseases associated with KcsA K + channel dysfunction. We recently discovered that artificial self-assembled n-alkyl-benzoureido-15-crown-5-ether form selective ion-channels for K + cations, which are highly preferred to Na + cations. Here, we describe an impressive selective activation of the K + transport via electrogenic macrocycles, stimulated by the addition of the carbonyl cyanide-4-(trifluoromethoxy) phenylhydrazone (FCCP) proton carrier. The transport performances show that both the position of branching or the size of appended alkyl arms favor high transport activity and selectivity SK + /Na + up to 48.8, one of the best values reported up to now. Our study demonstrates that high K + /Na + selectivity obtained with natural KcsA K + channels is achievable using simpler artificial macrocycles displaying constitutional functions.

Domaines

Chimie
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Dates et versions

hal-03028983 , version 1 (27-11-2020)

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Yu-Hao Li, Shao-Ping Zheng, Dawei Wang, Mihail Barboiu. Selective Proton-Mediated Transport by Electrogenic K+-Binding Macrocycles. Chemistry, 2020, 2 (1), pp.11 - 21. ⟨10.3390/chemistry2010003⟩. ⟨hal-03028983⟩
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