Virtual offices give employees the ability to work anytime, anywhere, using information and communication technologies, thereby blurring the temporal and geographical boundaries of work. Workplace stress is thus allowed to spill over from traditional offices to virtual offices, and vice versa. This review article presents key research from work psychology and information systems on workplace stress experienced in virtual offices (interruptions, workload and the work-home interface). It further discusses the main threats faced by organizations and office managers: reduced social interactions, poor communication, and deviant behaviors. Suggestions are also offered to practitioners seeking to design virtual offices in which employees can feel and work well, and to academics seeking to research this phenomenon in a transdisciplinary way.