Human HOX Proteins Use Diverse and Context-Dependent Motifs to Interact with TALE Class Cofactors
Résumé
Graphical Abstract Highlights d The vast majority of human HOX proteins use diverse TALE-binding sites d The usage mode of TALE-binding sites is highly context specific d Several identified TALE-binding sites are short linear interaction motifs d A new TALE-binding site is important for the proliferative activity of HOXA7 In Brief Dard et al. examine interaction flexibility between HOX proteins and TALE cofactors. The authors identify specific TALE-binding sites in different human HOX proteins. Most of these TALE-binding sites correspond to short motifs that are differently used depending on the DNA-binding site or cell context.
Domaines
Sciences du Vivant [q-bio]Origine | Fichiers éditeurs autorisés sur une archive ouverte |
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