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Article Dans Une Revue Cell Reports Année : 2018

Human HOX Proteins Use Diverse and Context-Dependent Motifs to Interact with TALE Class Cofactors

Résumé

Graphical Abstract Highlights d The vast majority of human HOX proteins use diverse TALE-binding sites d The usage mode of TALE-binding sites is highly context specific d Several identified TALE-binding sites are short linear interaction motifs d A new TALE-binding site is important for the proliferative activity of HOXA7 In Brief Dard et al. examine interaction flexibility between HOX proteins and TALE cofactors. The authors identify specific TALE-binding sites in different human HOX proteins. Most of these TALE-binding sites correspond to short motifs that are differently used depending on the DNA-binding site or cell context.
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Dates et versions

hal-02996723 , version 1 (09-11-2020)

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Amélie Dard, Jonathan Reboulet, Yunlong Jia, Françoise Bleicher, Marilyne Duffraisse, et al.. Human HOX Proteins Use Diverse and Context-Dependent Motifs to Interact with TALE Class Cofactors. Cell Reports, 2018, 22, pp.3058 - 3071. ⟨10.1016/j.celrep.2018.02.070⟩. ⟨hal-02996723⟩
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