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Article Dans Une Revue Molecules Année : 2020

N-Heterocyclic Carbene Platinum(IV) as Metallodrug Candidates: Synthesis and 195Pt NMR Chemical Shift Trend

Bruno Vincent
  • Fonction : Auteur
Thierry Achard
Stéphane Bellemin-Laponnaz

Résumé

A series of octahedral platinum(IV) complexes functionalized with both N-heterocyclic carbene (NHC) ligands were synthesized according to a straightforward procedure and characterized. The coordination sphere around the metal was varied, investigating the influence of the substituted NHC and the amine ligand in trans position to the NHC. The influence of those structural variations on the chemical shift of the platinum center were evaluated by 195 Pt NMR. This spectroscopy provided more insights on the impact of the structural changes on the electronic density at the platinum center. Investigation of the in vitro cytotoxicities of representative complexes were carried on three cancer cell lines and showed IC 50 values down to the low micromolar range that compare favorably with the benchmark cisplatin or their platinum(II) counterparts bearing NHC ligands.
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Dates et versions

hal-02960887 , version 1 (25-11-2020)

Identifiants

Citer

Mathilde Bouché, Bruno Vincent, Thierry Achard, Stéphane Bellemin-Laponnaz. N-Heterocyclic Carbene Platinum(IV) as Metallodrug Candidates: Synthesis and 195Pt NMR Chemical Shift Trend. Molecules, 2020, 25 (14), pp.3148. ⟨10.3390/molecules25143148⟩. ⟨hal-02960887⟩
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