Accumulation of natriuretic peptides is associated with protein energy wasting and activation of browning in white adipose tissue in chronic kidney disease - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Kidney International Année : 2020

Accumulation of natriuretic peptides is associated with protein energy wasting and activation of browning in white adipose tissue in chronic kidney disease

Mathilde Luce
  • Fonction : Auteur
Christophe Barba
  • Fonction : Auteur
Emilie Bres
  • Fonction : Auteur
Elsa Nyam
  • Fonction : Auteur
Laetitia Koppe

Résumé

Protein energy wasting is a common feature of patients with chronic kidney disease (CKD) and is associated with poor outcomes. Protein energy wasting and cachexia, a severe form of protein energy wasting, are characterized by increased resting energy expenditure but the underlying mechanisms are unclear. Browning corresponds to the activation of inducible brown adipocytes in white adipose tissue and occurs in states of cachexia associated with hypermetabolic disease such as cancer. Here we tested the hypothesis that CKD-associated protein energy wasting could result from browning activation as a direct effect of the uremic environment on adipocytes. In a murine model of CKD (5/6 nephrectomy), there was increased resting energy expenditure, expression of uncoupling protein 1 (a thermogenic protein uncoupling oxidative phosphorylation in mitochondria) and citrate synthase activity (a proxy of mitochondria) density in white adipose tissue). Mice with CKD also exhibited increased levels of atrial natriuretic peptide, a well known activator of browning. The incubation of primary adipose cells with plasma from patients receiving dialysis treatment and having signs of protein energy wasting led to an increased synthesis of uncoupling protein 1. Similarly, primary adipose cells exposed to atrial natriuretic peptide at concentrations relevant of CKD led to a significant increase of uncoupling protein 1 content. Thus, accumulation of cardiac natriuretic peptides during CKD could contribute the browning of white adipose tissue and protein energy wasting.
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hal-02912107 , version 1 (22-08-2022)

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Paternité - Pas d'utilisation commerciale - Pas de modification

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Citer

Mathilde Luce, Christophe Barba, Dan Yi, Anne Mey, Damien Roussel, et al.. Accumulation of natriuretic peptides is associated with protein energy wasting and activation of browning in white adipose tissue in chronic kidney disease. Kidney International, 2020, 98 (3), pp.663-672. ⟨10.1016/j.kint.2020.03.027⟩. ⟨hal-02912107⟩
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