Co-exposure to internal and external radiation alters cesium biokinetics and retention in mice - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Journal of Radiological Protection Année : 2020

Co-exposure to internal and external radiation alters cesium biokinetics and retention in mice

Résumé

Exposures in post-accidental situations are complex and include both external exposure and internal contamination with several radionuclides. However, in vivo and in vitro studies generally use simplified exposures, while a recent study suggested that combined external irradiation and internal contamination may induce more severe biological effects as compared to single exposures. In an attempt to test the hypothesis of potential non-additive effects of multiple radiological exposures, we used a mouse model of combined external X rays irradiation and internal contamination with 137Cs injection. Results showed a differential kinetics of 137Cs elimination in irradiated animals as compared to sham-irradiated, 137Cs injected animals. Moreover, changes in plasma potassium and in testis weight were observed 38 days after irradiation and injection. These results demonstrate that a combination of an external exposure combined with an internal contamination may lead to unexpected changes in biokinetics and biological effects of internalized radionuclides.

Domaines

Toxicologie
Fichier principal
Vignette du fichier
0000161353_002.PDF (13.93 Mo) Télécharger le fichier
Origine : Fichiers produits par l'(les) auteur(s)
Loading...

Dates et versions

hal-02869303 , version 1 (15-06-2020)

Licence

Paternité - Pas d'utilisation commerciale - Pas de modification

Identifiants

Citer

Jean Marc Bertho, Raphael Bo, Victor Magneron, Audrey Legendre, Margaux Cochard, et al.. Co-exposure to internal and external radiation alters cesium biokinetics and retention in mice. Journal of Radiological Protection, 2020, 40, pp.504-519. ⟨10.1088/1361-6498/ab7b43⟩. ⟨hal-02869303⟩
33 Consultations
40 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More