Co-exposure to internal and external radiation alters cesium biokinetics and retention in mice
Résumé
Exposures in post-accidental situations are complex and include both external exposure and internal contamination with several radionuclides. However, in vivo and in vitro studies generally use simplified exposures, while a recent study suggested that combined external irradiation and internal contamination may induce more severe biological effects as compared to single exposures. In an attempt to test the hypothesis of potential non-additive effects of multiple radiological exposures, we used a mouse model of combined external X rays irradiation and internal contamination with 137Cs injection. Results showed a differential kinetics of 137Cs elimination in irradiated animals as compared to sham-irradiated, 137Cs injected animals. Moreover, changes in plasma potassium and in testis weight were observed 38 days after irradiation and injection. These results demonstrate that a combination of an external exposure combined with an internal contamination may lead to unexpected changes in biokinetics and biological effects of internalized radionuclides.
Domaines
Toxicologie
Origine : Fichiers produits par l'(les) auteur(s)
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