Light cleavage of some potential linkers for drug carriers
Résumé
The study of photocleavage of different substrates as potential linkers for drug carrier compounds is reported. The role of singlet oxygen and the kinetic rates implied in the photoreactions were determined. The study envisaged the use of two olefins: 7-(4-chlorophenyl)hept-6-enoic acid and 7-(ferrocene)hept-6-enoic acid as potential linkers for the controlled release of a specific drug, by singlet oxygen induced cleavage. The rate constants for quenching of the singlet oxygen by these olefins were determined. The photoproducts were analyzed by FTIR spectroscopy.