Comprehensive study of rodent olfactory tissue lipid composition - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Prostaglandins, Leukotrienes and Essential Fatty Acids Année : 2018

Comprehensive study of rodent olfactory tissue lipid composition

Résumé

The peripheral olfactory tissue (OT) plays a primordial role in the detection and transduction of olfactory information. Recent proteomic and transcriptomic studies have provided valuable insight into proteins and RNAs expressed in this tissue. Paradoxically, there is little information regarding the lipid composition of mammalian OT. To delve further into this issue, using a set of complementary state-of-the-art techniques, we carried out a comprehensive analysis of OT lipid composition in rats and mice fed with standard diets. The results showed that phospholipids are largely predominant, the major classes being phosphatidylcholine and phosphatidylethanolamine. Two types of plasmalogens, plasmenyl-choline and plasmenyl-ethanolamine, as well as gangliosides were also detected. With the exception of sphingomyelin, substantial levels of n-3 polyunsaturated fatty acids, mainly docosahexaenoic acid (22:6n-3; DHA), were found in the different phospholipid classes. These findings demonstrate that the rodent OT shares several features in common with other neural tissues, such as the brain and retina.
Fichier non déposé

Dates et versions

hal-02626619 , version 1 (26-05-2020)

Identifiants

Citer

Anne-Marie Le Bon, Nicolas Deprêtre, Estelle Sibille, Stéphanie Cabaret, Stéphane Grégoire, et al.. Comprehensive study of rodent olfactory tissue lipid composition. Prostaglandins, Leukotrienes and Essential Fatty Acids, 2018, 131, pp.32-43. ⟨10.1016/j.plefa.2018.03.008⟩. ⟨hal-02626619⟩
14 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More