AI-based multi-modal integration of clinical characteristics, lab tests and chest CTs improves COVID-19 outcome prediction of hospitalized patients
Nathalie Lassau
(1, 2)
,
Samy Ammari
(1, 2)
,
Emilie Chouzenoux
(3)
,
Hugo Gortais
(4)
,
Paul Herent
(5)
,
Matthieu Devilder
(4)
,
Samer Soliman
(4)
,
Olivier Meyrignac
(4)
,
Marie-Pauline Talabard
(4)
,
Jean-Philippe Lamarque
(1, 2)
,
Rémy Dubois
(5)
,
Nicolas Loiseau
(5)
,
Paul Trichelair
(5)
,
Etienne Bendjebbar
(5)
,
Gabriel C Garcia
(2)
,
Corinne Balleyguier
(1, 2)
,
Mansouria Merad
(6)
,
Annabelle Stoclin
(6)
,
Simon Jegou
(5)
,
Franck Griscelli
(6)
,
Nicolas Tetelboum
(2)
,
Yingping Li
(1)
,
Sagar Verma
(3)
,
Matthieu Terris
(3)
,
Tasnim Dardouri
(3)
,
Kavya Gupta
(3)
,
Ana Neacsu
(3)
,
Frank Chemouni
(6)
,
Meriem Sefta
(5)
,
Paul Jehanno
(5)
,
Imad Bousaid
(6)
,
Yannick Boursin
(6)
,
Emmanuel Planchet
(6)
,
Mikael Azoulay
(6)
,
Jocelyn Dachary
(5)
,
Fabien Brulport
(5)
,
Adrián González
(5)
,
Olivier Dehaene
(5)
,
Jean-Baptiste Schiratti
(5)
,
Kathryn Schutte
(5)
,
Jean-Christophe Pesquet
(3)
,
Hugues Talbot
(3)
,
Elodie Pronier
(5)
,
Gilles Wainrib
(5)
,
Thomas Clozel
(5)
,
Fabrice Barlesi
(6)
,
Marie-France Bellin
(1, 4)
,
Michael G B Blum
(5)
Nathalie Lassau
- Fonction : Auteur
- PersonId : 758207
- ORCID : 0000-0001-8068-6513
Emilie Chouzenoux
- Fonction : Auteur
- PersonId : 10209
- IdHAL : emilie-chouzenoux
- ORCID : 0000-0003-3631-6093
- IdRef : 192528572
Corinne Balleyguier
- Fonction : Auteur
- PersonId : 1241668
- ORCID : 0000-0002-0018-8731
- IdRef : 074537695
Yingping Li
- Fonction : Auteur
- PersonId : 743094
- IdHAL : yingping-li
Jean-Baptiste Schiratti
- Fonction : Auteur
- PersonId : 6658
- IdHAL : jean-baptiste-schiratti
- ORCID : 0000-0002-8797-1146
- IdRef : 197625320
Jean-Christophe Pesquet
- Fonction : Auteur
- PersonId : 8124
- IdHAL : jean-christophe-pesquet
- IdRef : 122058577
Hugues Talbot
- Fonction : Auteur
- PersonId : 1939
- IdHAL : hugues-talbot
- ORCID : 0000-0002-2179-3498
- IdRef : 181843056
Résumé
With 15% of severe cases among hospitalized patients, the SARS-COV-2 pandemic has put tremendous pressure on Intensive Care Units, and made the identification of early predictors of future severity a public health priority. We collected clinical and biological data, as well as CT scan images and radiology reports from 1,003 coronavirus-infected patients from two French hospitals. Radiologists' manual CT annotations were also available. We first identified 11 clinical variables and 3 types of radiologist-reported features significantly associated with prognosis. Next, focusing on the CT images, we trained deep learning models to automatically segment the scans and reproduce radiologists' annotations. We also built CT image-based deep learning models that predicted future severity better than models based on the radiologists' scan reports. Finally, we showed that including CT scan features alongside the clinical and biological data yielded more accurate predictions than using clinical and biological data alone. These findings show that CT scans provide insightful early predictors of future severity.
Origine : Fichiers produits par l'(les) auteur(s)
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