Trace elements can be accumulated from coastal environment to the aquatic organisms by their food and be transferred throughout the food webs. Studying the effects of salinity on the trophic transfer of trace elements in euryhaline organisms, able to deal with large variations in salinity, is therefore key to understand their dynamics in aquatic environments. In this context, we investigated the potential influence of salinity on the trophic transfer of two essential elements (Mn and Zn) in the euryhaline fish, the turbot Scophthalmus maximus using radiotracer techniques. After acclimation to three salinities (10, 25 and 38), juvenile turbots were fed with radiolabelled pellets (54Mn and 65Zn). Kinetic parameters of depuration were determined after a 21-d period and trophic transfer factors were calculated. Trophic transfer of Mn at the highest salinity was significantly lower than for the other conditions whereas salinity did not significantly influence Zn trophic transfer. Differences in the processes involved in the regulation (homeostasis) of the two tested trace elements may explain the contrasting influence of water salinity for Mn and Zn.