Ferritin iron core, Actinide uptake by transferrin and ferritin metalloproteins: two EXAFS studies - Archive ouverte HAL Accéder directement au contenu
Poster De Conférence Année : 2008

Ferritin iron core, Actinide uptake by transferrin and ferritin metalloproteins: two EXAFS studies

C. Barbot
Christophe den Auwer
Isabelle Llorens
  • Fonction : Auteur
Philippe Moisy
Claude Vidaud
  • Fonction : Auteur
P- L. Solari
  • Fonction : Auteur
Valérie Briois
  • Fonction : Auteur
  • PersonId : 1060718
H. Funke
  • Fonction : Auteur

Résumé

In order to better understand the mechanisms of actinide uptakeby specific biomolecules, it is essential to explore the intramolecular interactions between the cation and the protein binding site. Although this has long been done for widely investigated transition metals, very few studies have been devoted to complexation mechanisms of actinides by active chelation sitesof metalloproteins. In this field, X-ray absorption spectroscopy has been extensively used as a structural and electronic metal cation probe. The two examples that are presented here are related totwo metalloproteins in charge of iron transport and storage in eukaryote cells: transferrin and ferritin. U(VI)O22+, Np(IV) and Pu(IV) have been selected because of their possible role as contaminant from the geosphere.
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hal-02535591 , version 1 (10-04-2020)

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  • HAL Id : hal-02535591 , version 1

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C. Barbot, Christophe den Auwer, Guy G. Ouvrard, Isabelle Llorens, Philippe Moisy, et al.. Ferritin iron core, Actinide uptake by transferrin and ferritin metalloproteins: two EXAFS studies. AECCPCM, Apr 2008, Marseille, France. ⟨hal-02535591⟩
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