Access to Unprotected β-Fluoroalkyl β-Amino Acids and Their α-Hydroxy Derivatives
Résumé
Unprotected -(het)aryl--fluoroalkyl -amino acids and their -hydroxy derivatives can be readily obtained using a decarboxylative Mannich-type reaction without protection/deprotection steps. This protocol utilizes lithium hexamethyldisilazide and (het)arylfluoroalkyl ketones to generate NH-ketimine intermediates. The mild reaction conditions allow the preparation of original fluorinated -amino acids as useful building blocks in a practical and scalable manner.
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Access to Unprotected β-Fluoroalkyl β-Amino Acids and Their α-Hydroxy Derivatives.pdf (1.6 Mo)
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