Access to Unprotected β-Fluoroalkyl β-Amino Acids and Their α-Hydroxy Derivatives - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Organic Letters Année : 2019

Access to Unprotected β-Fluoroalkyl β-Amino Acids and Their α-Hydroxy Derivatives

Résumé

Unprotected -(het)aryl--fluoroalkyl -amino acids and their -hydroxy derivatives can be readily obtained using a decarboxylative Mannich-type reaction without protection/deprotection steps. This protocol utilizes lithium hexamethyldisilazide and (het)arylfluoroalkyl ketones to generate NH-ketimine intermediates. The mild reaction conditions allow the preparation of original fluorinated -amino acids as useful building blocks in a practical and scalable manner.
Fichier principal
Vignette du fichier
Access to Unprotected β-Fluoroalkyl β-Amino Acids and Their α-Hydroxy Derivatives.pdf (1.6 Mo) Télécharger le fichier
Origine Fichiers produits par l'(les) auteur(s)
Loading...

Dates et versions

hal-02501233 , version 1 (06-03-2020)

Identifiants

Citer

Volodymyr Sukach, Serhii Melnykov, Sylvain Bertho, Iryna Diachenko, Pascal Retailleau, et al.. Access to Unprotected β-Fluoroalkyl β-Amino Acids and Their α-Hydroxy Derivatives. Organic Letters, 2019, 21 (7), pp.2340-2345. ⟨10.1021/acs.orglett.9b00622⟩. ⟨hal-02501233⟩
49 Consultations
174 Téléchargements

Altmetric

Partager

Gmail Mastodon Facebook X LinkedIn More