Neuromorphic systems are designed by mimicking or being inspired by the nervous system, which realizes robust, autonomous, and power-efficient information processing by highly parallel architecture. Supervised learning was proposed as a successful concept of information processing in neural network. Recently, there has been an increasing body of evidence that instruction-based learning is also exploited by the brain. ReSuMe is a proposed algorithm by Ponulak and Kasinski in 2010. It proposes a supervised learning for biologically plausible neurons that reproduce template signals (instructions) or patterns encoded in precisely timed sequences of spikes. Here, we present a real-time ReSuMe learning implementation on FPGA using Leaky Integrate-and-fire (LIF) Spiking Neural Network (SNN). FPGA allows real-time implementation and embedded system. We show that this implementation can make successful the learning on a specific pattern.