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Article Dans Une Revue Glia Année : 2019

Role of astrocyte purinergic signaling in epilepsy

Paola Nobili
  • Fonction : Auteur
Weida Shen
  • Fonction : Auteur
Etienne Audinat

Résumé

Epilepsy is characterized by unpredictable recurrent seizures resulting from hypersynchronous discharges from neuron assemblies. Increasing evidence indicates that aberrant astrocyte signaling to neurons plays an important role in driving the network hyperexcitability. Purinergic signaling is central in neuron-glia and glia-glia interactions and dysfunctions in communication pathways involving purinergic receptors have been reported in various CNS pathologies, such as Alzheimer disease, stroke, major depression, schizophrenia, and epilepsy. In the present review we will first discuss the mechanisms by which astrocytes influence neuronal activity. We will then review in more details recent evidence indicating that dysregulation of astrocyte purinergic signaling actively contributes to the appearance of abnormal neuronal activity in epilepsy.
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Dates et versions

hal-02400360 , version 1 (20-11-2020)

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Ljiljana Nikolic, Paola Nobili, Weida Shen, Etienne Audinat. Role of astrocyte purinergic signaling in epilepsy. Glia, 2019, ⟨10.1002/glia.23747⟩. ⟨hal-02400360⟩
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