Synthesis of N-(Hetero)arylconvolvine Derivatives through a Palladium-Catalyzed Buchwald–Hartwig Cross-Coupling
Résumé
The present study describes the isolation of convolvine from the roots of the Tunisian plant Convolvulus dorycnium L. and it's synthesis through a four-steps sequence starting from tropine. Then, an efficient synthesis of N-(het)aryl tropanes derivativesby a sequence of a palladium-catalyzed N-arylationof convolvine has been established. This strategyenabled an access to unknown tropane scaffolds of biological interests.
Domaines
CatalyseOrigine | Fichiers produits par l'(les) auteur(s) |
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