Synthesis of N-(Hetero)arylconvolvine Derivatives through a Palladium-Catalyzed Buchwald–Hartwig Cross-Coupling - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Synthesis: Journal of Synthetic Organic Chemistry Année : 2019

Synthesis of N-(Hetero)arylconvolvine Derivatives through a Palladium-Catalyzed Buchwald–Hartwig Cross-Coupling

Résumé

The present study describes the isolation of convolvine from the roots of the Tunisian plant Convolvulus dorycnium L. and it's synthesis through a four-steps sequence starting from tropine. Then, an efficient synthesis of N-(het)aryl tropanes derivativesby a sequence of a palladium-catalyzed N-arylationof convolvine has been established. This strategyenabled an access to unknown tropane scaffolds of biological interests.

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Catalyse
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Dates et versions

hal-02396680 , version 1 (06-12-2019)

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Citer

Manel Hassine, Hichem Ben Jannet, Noureddine Ghermani, Mouad Alami, Samir Messaoudi. Synthesis of N-(Hetero)arylconvolvine Derivatives through a Palladium-Catalyzed Buchwald–Hartwig Cross-Coupling. Synthesis: Journal of Synthetic Organic Chemistry, 2019, ⟨10.1055/s-0039-1690238⟩. ⟨hal-02396680⟩
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