Interaction of a Model Peptide on Gram Negative and Gram Positive Bacterial Sliding Clamps - Archive ouverte HAL Access content directly
Journal Articles ACS Infectious Diseases Year : 2019

Interaction of a Model Peptide on Gram Negative and Gram Positive Bacterial Sliding Clamps

Abstract

Bacterial sliding clamps control the access of DNA polymerases to the replication fork and are appealing molecular targets for antibacterial drugs development. To this end, it is critical to decipher the polymerase-clamp binding mode across various bacterial species. We showed previously that synthetic peptides targeting the clamp binding pocket of Gram-bacteria poorly interact with that of Gram+ homologous proteins. Here we analyzed the interaction of a reference peptide with several E. coli and B. subtilis clamp variants. For both Gram-and Gram+ pockets, the peptide binds through an induced-fit process but the complex stability
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Dates and versions

hal-02379658 , version 1 (25-11-2019)

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Christophe André, Isabelle Martiel, Philippe Wolff, Marie Landolfo, Bernard Lorber, et al.. Interaction of a Model Peptide on Gram Negative and Gram Positive Bacterial Sliding Clamps. ACS Infectious Diseases, 2019, 5 (6), pp.1022-1034. ⟨10.1021/acsinfecdis.9b00089⟩. ⟨hal-02379658⟩
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