Structural basis for chemically-induced homodimerization of a single domain antibody - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Scientific Reports Année : 2019

Structural basis for chemically-induced homodimerization of a single domain antibody

Résumé

Chemically-induced dimerization (CID) systems are essential tools to interrogate and control biological systems. AcVHH is a single domain antibody homo-dimerizing upon caffeine binding. AcVHH has a strong potential for clinical applications through caffeine-mediated in vivo control of therapeutic gene networks. Here we provide the structural basis for caffeine-induced homo-dimerization of acVHH.
Fichier principal
Vignette du fichier
s41598-019-38752-y.pdf (1.11 Mo) Télécharger le fichier
Origine : Fichiers éditeurs autorisés sur une archive ouverte

Dates et versions

hal-02363539 , version 1 (02-03-2021)

Licence

Paternité

Identifiants

Citer

Jean Lesné, Hung-Ju Chang, Angelique de Visch, Matteo Paloni, Philippe Barthe, et al.. Structural basis for chemically-induced homodimerization of a single domain antibody. Scientific Reports, 2019, 9 (1), ⟨10.1038/s41598-019-38752-y⟩. ⟨hal-02363539⟩
47 Consultations
110 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More