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Article Dans Une Revue PLoS ONE Année : 2018

A new bioabsorbable polymer film to prevent peritoneal adhesions validated in a post-surgical animal model

Résumé

BACKGROUND: Peritoneal adhesions are a serious surgical postoperative complication. The aim of this study is to investigate, in a rat model, the anti-adhesive effects of a bioabsorbable film of polymer combining polyethylene glycol and polylactic acid. MATERIALS AND METHODS: Sixty-three animals were randomized into five groups according to the anti-adhesion treatment: Hyalobarrier\textregistered, Seprafilm\textregistered, Polymer A (PA), Polymer B (PB), and control. The rats were euthanized on days 5 and 12 to evaluate the extent, severity and degree of adhesions and histopathological changes. Three animals were euthanized at day 2 in PA, PB and control groups to observe the in vivo elimination. RESULTS: Macroscopic adhesion formation was significantly lower in the PA group than in the control group at day 5 (median adhesion score 0\textpm0 vs 9.6 \textpm0.5 p = 0.002) and at day 12 (0\textpm0 vs 7.3\textpm4 p = 0.02). Furthermore, median adhesion score at day 5 was significantly lower in the PA group than in the Seprafilm group (0\textpm0 vs 4.2\textpm 3.9 p = 0.03). Residence time of PA seems longer than PB. CONCLUSION: The PA bioabsorbable film seems efficient in preventing the formation of peritoneal adhesions.
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hal-02359782 , version 1 (25-02-2020)

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Lucie Allègre, Isabelle Le Teuff, Salomé Leprince, Sophie Warembourg, Hubert Taillades, et al.. A new bioabsorbable polymer film to prevent peritoneal adhesions validated in a post-surgical animal model. PLoS ONE, 2018, 13 (11), pp.e0202285. ⟨10.1371/journal.pone.0202285⟩. ⟨hal-02359782⟩
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