We consider the Cauchy problem of the nonlinear Landau equation of Maxwellian molecules, under the perturbation frame work to global equilibrium. We show that if H r x (L 2 v), r > 3/2 norm of the initial perturbation is small enough, then the Cauchy problem of the nonlinear Landau equation admits a unique global solution which becomes analytic with respect to both position x and velocity v variables for any time t > 0. This is the first result of analytic smoothing effect for the spatially inhomogeneous nonlinear kinetic equation. The method used here is microlocal analysis and energy estimates. The key point is adopting a time integral weight associated with the kinetic transport operator.