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Article Dans Une Revue European Journal of Organic Chemistry Année : 2018

Synthesis of SAM-Adenosine Conjugates for the Study of m 6 A-RNA Methyltransferases

Résumé

RNA methyltransferases (RNMTs) catalyze the methyl-ation of RNA using S-adenosyl-L-methionine (SAM) as the methyl donor. Methylation at the N-6 position of adenosine is the most abundant modification found in nearly all classes of RNAs and contributes to the regulation of many biological processes in the three domains of life. However, this family of enzymes remains relatively unexplored by the medicinal chemis

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Chimie
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Dates et versions

hal-02353523 , version 1 (20-04-2022)

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Colette Atdjian, Laura Iannazzo, Emmanuelle Braud, Mélanie Ethève-Quelquejeu. Synthesis of SAM-Adenosine Conjugates for the Study of m 6 A-RNA Methyltransferases. European Journal of Organic Chemistry, 2018, 2018 (32), pp.4411-4425. ⟨10.1002/ejoc.201800798⟩. ⟨hal-02353523⟩
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