Synthesis of SAM-Adenosine Conjugates for the Study of m 6 A-RNA Methyltransferases
Résumé
RNA methyltransferases (RNMTs) catalyze the methyl-ation of RNA using S-adenosyl-L-methionine (SAM) as the methyl donor. Methylation at the N-6 position of adenosine is the most abundant modification found in nearly all classes of RNAs and contributes to the regulation of many biological processes in the three domains of life. However, this family of enzymes remains relatively unexplored by the medicinal chemis