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Article Dans Une Revue European Journal of Medicinal Chemistry Année : 2009

New imidazo[1,2-a]quinoxaline derivatives: Synthesis and in vitro activity against human melanoma

Résumé

New imidazo[1,2-a]quinoxaline analogues have been synthesized in good yields via a bimolecular condensation of 2-imidazole carboxylic acid, followed by a coupling with ortho-fluoroaniline and subsequent substitution on the imidazole ring by Suzuki Cross-coupling reaction using microwave assistance. Antitumor activities of these derivatives were evaluated by growth inhibition of A375 cells in vitro. All compounds exhibited high activities compared to imiquimod and fotemustine used as references.
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Dates et versions

hal-02309640 , version 1 (09-10-2019)

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Carine Deleuze-Masquéfa, Georges Moarbess, Sonia Khier, Nadège David, Stéphanie Gayraud-Paniagua, et al.. New imidazo[1,2-a]quinoxaline derivatives: Synthesis and in vitro activity against human melanoma. European Journal of Medicinal Chemistry, 2009, 44 (9), pp.3406-3411. ⟨10.1016/j.ejmech.2009.02.007⟩. ⟨hal-02309640⟩
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