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Article Dans Une Revue Current Opinion in Biotechnology Année : 2017

Multidimensional NMR approaches towards highly resolved, sensitive and high-throughput quantitative metabolomics

Résumé

Multi-dimensional NMR is an appealing approach for dealing with the challenging complexity of biological samples in metabolomics. This article describes how spectroscopists have recently challenged their imagination in order to make 2D NMR a powerful tool for quantitative metabolomics, based on innovative pulse sequences combined with meticulous analytical chemistry approaches. Clever time-saving strategies have also been explored to make 2D NMR a high-throughput tool for metabolomics, relying on alternative data acquisition schemes such as ultrafast NMR. Currently, much work is aimed at drastically boosting the NMR sensitivity thanks to hyperpolarisation techniques, which have been used in combination with fast acquisition methods and could greatly expand the application potential of NMR metabolomics.

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Chimie
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Dates et versions

hal-02141306 , version 1 (27-05-2019)

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Jérémy Marchand, Estelle Martineau, Yann Guitton, Gaud Dervilly-Pinel, Patrick Giraudeau. Multidimensional NMR approaches towards highly resolved, sensitive and high-throughput quantitative metabolomics. Current Opinion in Biotechnology, 2017, 43, pp.49-55. ⟨10.1016/j.copbio.2016.08.004⟩. ⟨hal-02141306⟩
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