The Epigenetic Trans-Silencing Effect in Drosophila Involves Maternally-Transmitted Small RNAs Whose Production Depends on the piRNA Pathway and HP1 - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue PLoS ONE Année : 2010

The Epigenetic Trans-Silencing Effect in Drosophila Involves Maternally-Transmitted Small RNAs Whose Production Depends on the piRNA Pathway and HP1

Résumé

Background: The study of P transposable element repression in Drosophila melanogaster led to the discovery of the Trans-Silencing Effect (TSE), a homology-dependent repression mechanism by which a P-transgene inserted in subtelomeric heterochromatin (Telomeric Associated Sequences, ''TAS'') has the capacity to repress in trans, in the female germline, a homologous P-lacZ transgene located in euchromatin. Phenotypic and genetic analysis have shown that TSE exhibits variegation in ovaries, displays a maternal effect as well as epigenetic transmission through meiosis and involves heterochromatin (including HP1) and RNA silencing.
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hal-02116134 , version 1 (30-04-2019)

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Anne-Laure Todeschini, Laure Teysset, Valerie Delmarre, Stéphane Ronsseray. The Epigenetic Trans-Silencing Effect in Drosophila Involves Maternally-Transmitted Small RNAs Whose Production Depends on the piRNA Pathway and HP1. PLoS ONE, 2010, 5 (6), pp.e11032. ⟨10.1371/journal.pone.0011032⟩. ⟨hal-02116134⟩
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